Cychlorphine, a potent synthetic opioid, has been associated with numerous fatalities across the U.S., especially in Tennessee, where over 30 deaths have been reported since October 2025. The drug is said to be up to ten times more potent than fentanyl and can lead to respiratory failure. It is not approved for medical use and is often found in counterfeit pills. Health officials warn that standard drug tests do not detect cychlorphine, complicating overdose responses, which may require multiple doses of naloxone to reverse.
Key facts
- Cychlorphine linked to over 30 deaths in Tennessee since October 2025.
- At least 55 deaths linked to cychlorphine reported nationwide.
- Cychlorphine is reportedly up to 10 times more potent than fentanyl.
- Standard drug tests do not detect cychlorphine.
- Multiple doses of naloxone may be needed to reverse its effects.
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