The San Francisco 49ers are preparing for their divisional matchup against the Seattle Seahawks on Sunday, with several players dealing with injuries. The 49ers currently lead the NFC West but faced a significant loss in their last encounter with the Seahawks during the NFC Divisional Round. Here are the latest updates on key players ahead of the game.
Wide receiver Mike Evans played through injury in the 49ers' Week 4 victory over the Denver Broncos, despite suffering from broken ribs. He recorded 76 yards on five receptions in that game. During Thursday's practice, Evans was seen running on the side field in uniform, although he did not participate in team drills. His status for the game against the Seahawks remains uncertain, but his activity is viewed as a positive sign for the team.
Defensive lineman Javon Williams is expected to make his season debut against Seattle. He is recovering from a torn ACL and lateral meniscus in his right knee, injuries sustained in November 2025. Based on his performance during Thursday's practice, Williams appears ready to play in Week 5.
Defensive end Nick Bosa is dealing with a calf injury and is anticipated to miss his third consecutive game against the Seahawks as he continues to recover. He was observed working off to the side during Thursday's practice.
Running back Christian McCaffrey and Williams both participated in practice on Thursday after resting on Wednesday, indicating they are prepared for the upcoming matchup against Seattle.